Kinetic evidence for heterogeneity in Na+-D-glucose cotransport systems in the normal human fetal small intestine.

@article{Malo1988KineticEF,
  title={Kinetic evidence for heterogeneity in Na+-D-glucose cotransport systems in the normal human fetal small intestine.},
  author={Christiane Malo},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={938 2},
  pages={181-8}
}
Zero-trans kinetic studies of Na+-D-glucose cotransport have been performed under voltage-clamped conditions in brush-border membrane vesicles isolated from both jejunum and ileum of 17-20-week-old normal human fetuses. Varying glucose concentrations in the incubation medium led to curvilinear Eadie-Hofstee plots in the jejunum only, thus suggesting the presence of both high-affinity, low-capacity (Km 0.37 mM; Vmax 8.3 nmol/min per mg protein) and low-affinity, high-capacity (Km 4.2 mM; Vmax 30… CONTINUE READING

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