Kinetic evidence for a common binding site for substrates and inhibitors of the neuronal noradrenaline carrier

@article{Schmig1988KineticEF,
  title={Kinetic evidence for a common binding site for substrates and inhibitors of the neuronal noradrenaline carrier},
  author={Edgar Sch{\"o}mig and M. K{\"o}rber and Heinz B{\"o}nisch},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={337},
  pages={626-632}
}
The neuronal noradrenaline uptake mechanism (uptake1) has been further characterized. For a number of substrates of uptake, the half-saturating concentration (K m) and the maximal initial transport rate (V max) were determined. Furthermore, the dissociation constants (K D) for binding of these substrates to the desipramine binding site of the neuronal noradrenaline carrier were measured. The uptake experiments were done on rat phaeochromocytoma cells (PC12 cells), the binding experiments on… CONTINUE READING

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PC12 pheochromocytoma cultures in neurobiological research

  • LA Greene, AS Tischler
  • Adv Cell Neurobiol
  • 1982
Highly Influential
3 Excerpts

The transport of amines across the axonal membranes of noradrenergic and dopaminergic neurones

  • KH Graefe
  • Handb Exp Pharmacol (Catecholamines II),
  • 1988

The noradrenaline transport system of PC-t2 cells: Kinetic analysis of the interaction between noradrenaline, Na + and C1- in transport

  • U Friedrich
  • Naunyn-Schmiedeberg's Arch Pharmacol
  • 1986
1 Excerpt

The transport of ( + ) amphetamine by the neuronal noradrenaline carrier

  • H nisch, R Harder
  • 1984

Characterization of 3Hdesipramine binding associated with norepinephrine uptake sites in rat brain membranes

  • CM Lee, JA Javitsch, SH Snyder
  • J Neurosci
  • 1982
2 Excerpts

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