Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha.

  title={Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha.},
  author={Simon Bergqvist and Vera Alverdi and Benedicte Mengel and Alexander Hoffmann and Gourisankar Ghosh and Elizabeth A. Komives},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 46},
A hallmark of the NF-kappaB transcription response to inflammatory cytokines is the remarkably rapid rate of robust activation and subsequent signal repression. Although the rapidity of postinduction repression is explained partly by the fact that the gene for IkappaBalpha is strongly induced by NF-kappaB, the newly synthesized IkappaBalpha still must enter the nucleus and compete for binding to NF-kappaB with the very large number of kappaB sites in the DNA. We present results from real-time… CONTINUE READING


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