Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus.

@article{Jilg2014KineticDI,
  title={Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus.},
  author={Nikolaus Jilg and Wenyu Lin and Jian Hong and Esperance A K Schaefer and David Wolski and James Meixong and Kaku Goto and Cynthia Brisac and Pattranuch Chusri and Dahlene Fusco and St{\'e}phane Chevaliez and Jay Luther and Kattareeya Kumthip and Thomas J. Urban and Lee F. Peng and Georg M Lauer and Raymond Tsang Chi Chung},
  journal={Hepatology},
  year={2014},
  volume={59 4},
  pages={
          1250-61
        }
}
UNLABELLED Several genome-wide association studies (GWAS) have identified a genetic polymorphism associated with the gene locus for interleukin 28B (IL28B), a type III interferon (IFN), as a major predictor of clinical outcome in hepatitis C. Antiviral effects of the type III IFN family have previously been shown against several viruses, including hepatitis C virus (HCV), and resemble the function of type I IFN including utilization of the intracellular Janus kinase signal transducer and… CONTINUE READING
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