Kinetic differences in cardiac myosins with identical loop 1 sequences.

@article{Pereira2001KineticDI,
  title={Kinetic differences in cardiac myosins with identical loop 1 sequences.},
  author={Juliana Sousa Pereira and Dmitry Pavlov and Mahta Nili and Marion Greaser and Earl E Homsher and Richard L Moss},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 6},
  pages={
          4409-15
        }
}
The kinetics of nucleotide turnover vary considerably among isoforms of vertebrate type II myosin, possibly due to differences in the rate of ADP release from the nucleotide binding pocket. Current ideas about likely mechanisms by which ADP release is regulated have focused on the hyperflexible surface loops of myosin, i.e. loop 1 (ATPase loop) and loop 2 (actin binding loop). In the present study, we investigated the kinetic properties of rat and pig beta-myosin heavy chains (beta-MHC) in… CONTINUE READING
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