Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and (1)H NMR.

Abstract

Hydrolysis of insulin has been studied during storage of various preparations at different temperatures. Deamidation is the predominant degradation process in acid solution resulting in a desamido product. The current study examines whether the interaction of insulin with methyl-beta cyclodextrin (met beta CD) improves its stability. Hydrolysis of insulin… (More)

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