Kinetic characterization of the ATPase cycle of the DnaK molecular chaperone.

@article{Russell1998KineticCO,
  title={Kinetic characterization of the ATPase cycle of the DnaK molecular chaperone.},
  author={Rick Russell and Robert Jordan and Roger McMacken},
  journal={Biochemistry},
  year={1998},
  volume={37 2},
  pages={596-607}
}
DnaK, the prototype Hsp70 protein of Escherichia coli, functions as a molecular chaperone in protein folding and protein disassembly reactions through cycles of polypeptide binding and release that are coupled to its intrinsic ATPase activity. To further our understanding of these processes, we sought to obtain a quantitative description of the basic ATPase cycle of DnaK. To this end, we have performed steady-state and pre-steady-state kinetics experiments and have determined rate constants… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…