Kinetic characterization of recombinant mouse retinal dehydrogenase types 3 and 4 for retinal substrates.

Abstract

BACKGROUND Retinal dehydrogenases (RALDHs) catalyze the dehydrogenation of retinal into retinoic acids (RAs), which are required for embryogenesis and tissue differentiation. This study sought to determine the detailed kinetic properties of 2 mouse RALDHs, namely RALDH3 and 4, for retinal isomer substrates, to better define their specificities in RA isomer… (More)
DOI: 10.1016/j.bbagen.2009.09.004

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