Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.

Abstract

Glutaminase catalyzes the hydrolysis of glutamine to glutamate and plays a central role in the proliferation of neoplastic cells via glutaminolysis, as well as in the generation of excitotoxic glutamate in central nervous system disorders such as HIV-associated dementia (HAD) and multiple sclerosis. Both glutaminase siRNA and glutaminase inhibition have… (More)
DOI: 10.1016/j.bbrc.2013.06.110

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Cite this paper

@article{Thomas2013KineticCO, title={Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.}, author={Ajit G. Thomas and Camilo Rojas and Cordelle Tanega and Min Shen and Anton Simeonov and Matthew B. Boxer and Douglas S. Auld and Dana V Ferraris and Takashi Tsukamoto and Barbara S Slusher}, journal={Biochemical and biophysical research communications}, year={2013}, volume={438 2}, pages={243-8} }