Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures

@article{Hertz2004KineticCO,
  title={Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures},
  author={L. Hertz and A. Schousboe and N. Boechler and S. Mukerji and S. Fedoroff},
  journal={Neurochemical Research},
  year={2004},
  volume={3},
  pages={1-14}
}
  • L. Hertz, A. Schousboe, +2 authors S. Fedoroff
  • Published 2004
  • Biology, Medicine
  • Neurochemical Research
  • Kinetics for uptake and release of glutamate were measured in normal, i.e., nontransformed, astrocytes in cultures obtained from the dissociated, cortexenriched superficial parts of the brain hemispheres of newborn DBA mice. The uptake kinetics indicated a minor, unsaturable component together with an intense uptake following Michaelis-Menten kinetics. TheKm (50 μM) was reasonably comparable to the corresponding values in brain slices and in other glial preparations. TheVmax (58.8 nmol min−1 mg… CONTINUE READING
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