Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle.

@article{Guo1987KineticBF,
  title={Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle.},
  author={Xiaoyan Guo and Akira Uehara and A D Ravindran and Shirley H. Bryant and Syd Hall and Edward G. Moczydlowski},
  journal={Biochemistry},
  year={1987},
  volume={26 24},
  pages={7546-56}
}
The single-channel blocking kinetics of tetrodotoxin (TTX), saxitoxin (STX), and several STX derivatives were measured for various Na-channel subtypes incorporated into planar lipid bilayers in the presence of batrachotoxin. The subtypes studied include Na channels from rat skeletal muscle and rat brain, which have high affinity for TTX/STX, and Na channels… CONTINUE READING