Kinetic aspects of drug disposition in the lungs.

  title={Kinetic aspects of drug disposition in the lungs.},
  author={Richard N Upton and David J. Doolette},
  journal={Clinical and experimental pharmacology & physiology},
  volume={26 5-6},
1. The pharmacokinetic role of the lungs has been extensively studied using in vitro preparations, but this information has not been well integrated into many systemic pharmacokinetic models. 2. The lung is characterized by short diffusion distances, extremely high relative perfusion and heterogeneous cell types. Anionic and neutral lipophilic drugs have relatively small distribution volumes in the lungs due to their low lipid content. Cationic lipophilic drugs can accumulate in the lungs… CONTINUE READING

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