Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulation.

  title={Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulation.},
  author={Kristine Steen Jensen and Rosa E. Hansen and Jakob R Winther},
  journal={Antioxidants & redox signaling},
  volume={11 5},
Regulation of intracellular thiol-disulfide redox status is an essential part of cellular homeostasis. This involves the regulation of both oxidative and reductive pathways, production of oxidant scavengers and, importantly, the ability of cells to respond to changes in the redox environment. In the cytosol, regulatory disulfide bonds are typically formed in spite of the prevailing reducing conditions and may thereby function as redox switches. Such disulfide bonds are protected from enzymatic… CONTINUE READING

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