Kinetic and mechanistic characterisation of Choline Kinase-α.

  title={Kinetic and mechanistic characterisation of Choline Kinase-α.},
  author={Catherine S Hudson and Ronald M. A. Knegtel and Kieron Brown and Peter A. Charlton and John Robert Pollard},
  journal={Biochimica et biophysica acta},
  volume={1834 6},
Choline Kinase is a key component of the Kennedy pathway that converts choline into a number of structural and signalling lipids that are essential for cell growth and survival. One member of the family, Choline Kinase-α (ChoKα) is frequently up-regulated in human cancers, and expression of ChoKα is sufficient to transform cells. Consequently ChoKα has been studied as a potential target for therapeutic agents in cancer research. Despite great interest in the enzyme, mechanistic studies have not… CONTINUE READING
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