Kinetic and functional analysis of the heparin-binding domain of fibronectin

Abstract

We have previously shown that the heparin-binding domain of fibronectin (FN-HBD) enhances cell adhesion and proliferation of osteoblasts. Here we demonstrated that FN-HBD binds to heparin with a KD of 5 μM. Although, FN-HBD itself produces a modest effect on cell adhesion in the absence of central cell-binding domain (CCBD), FN-HBD significantly enhances… (More)
DOI: 10.1007/s10529-007-9522-3

Topics

5 Figures and Tables