Kinetic and dynamic studies of liposomal bupivacaine and bupivacaine solution after subcutaneous injection in rats.

@article{Yu2002KineticAD,
  title={Kinetic and dynamic studies of liposomal bupivacaine and bupivacaine solution after subcutaneous injection in rats.},
  author={H Y Yu and Shyh-Dar Li and Pin Sun},
  journal={The Journal of pharmacy and pharmacology},
  year={2002},
  volume={54 9},
  pages={1221-7}
}
The pharmacodynamics and pharmacokinetics of bupivacaine in solution and in liposome preparations following subcutaneous administration were studied in rats. Multilamellar vesicles entrapping bupivacaine solution were prepared. The local anaesthetic effect was estimated by the tail-flick test in Wistar rats treated with 1 mg bupivacaine in 0.2-mL preparations. Plasma concentrations of bupivacaine were determined by high-performance liquid chromatography. The results showed that both bupivacaine… CONTINUE READING

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