Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.

@article{Jordan1990KineticAO,
  title={Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.},
  author={Mary Ann Jordan and Leslie Kreiner Wilson},
  journal={Biochemistry},
  year={1990},
  volume={29 11},
  pages={
          2730-9
        }
}
We have investigated the effects of vinblastine at micromolar concentrations and below on the dynamics of tubulin exchange at the ends of microtubule-associated-protein-rich bovine brain microtubules. The predominant behavior of these microtubules at polymer-mass steady state under the conditions examined was tubulin flux, i.e., net addition of tubulin at one end of each microtubule, operationally defined as the assembly or A end, and balanced net loss at the opposite (disassembly or D) end. No… CONTINUE READING

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