Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis.

@article{Lu2012KineticAO,
  title={Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis.},
  author={Mengxiao Lu and Donald L. Gantz and Haya Herscovitz and Olga Gursky},
  journal={Journal of lipid research},
  year={2012},
  volume={53 10},
  pages={2175-85}
}
Fusion of modified LDL in the arterial wall promotes atherogenesis. Earlier we showed that thermal denaturation mimics LDL remodeling and fusion, and revealed kinetic origin of LDL stability. Here we report the first quantitative analysis of LDL thermal stability. Turbidity data show sigmoidal kinetics of LDL heat denaturation, which is unique among… CONTINUE READING