Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.

Abstract

The aim of this study was to develop a pharmacokinetic model to describe the transplacental transfer of drugs, based on the human placental perfusion study. The maternal and fetal sides of human placentas were perfused with salicylic acid together with antipyrine, a passive diffusion marker. The drug concentration in the placental tissue was determined at… (More)

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Cite this paper

@article{Shintaku2007KineticAO, title={Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.}, author={Kyohei Shintaku and Yuka Arima and Yukihiko Dan and Tsutomu Takeda and Kentaro Kogushi and Masayuki Tsujimoto and Hideaki Nagata and Shoji Satoh and Kiyomi Tsukimori and Hitoo Nakano and Satoko Hori and Hisakazu Ohtani and Yasufumi Sawada}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2007}, volume={35 5}, pages={772-8} }