Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.

@article{Mowla2018KineticAO,
  title={Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.},
  author={Rumana Mowla and Yinhu Wang and Shutao Ma and Henrietta Venter},
  journal={Biochimica et biophysica acta},
  year={2018},
  volume={1860 4},
  pages={878-886}
}
Multidrug efflux protein complexes such as AcrAB-TolC from Escherichia coli are paramount in multidrug resistance in Gram-negative bacteria and are also implicated in other processes such as virulence and biofilm formation. Hence efflux pump inhibition, as a means to reverse antimicrobial resistance in clinically relevant pathogens, has gained increased… CONTINUE READING