Kinetic Modelling of GlmU Reactions – Prioritization of Reaction for Therapeutic Application

@article{Singh2012KineticMO,
  title={Kinetic Modelling of GlmU Reactions – Prioritization of Reaction for Therapeutic Application},
  author={Vivek Kumar Singh and Kaveri S Das and Kothandaraman Seshadri},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
Mycobacterium tuberculosis(Mtu), a successful pathogen, has developed resistance against the existing anti-tubercular drugs necessitating discovery of drugs with novel action. Enzymes involved in peptidoglycan biosynthesis are attractive targets for antibacterial drug discovery. The bifunctional enzyme mycobacterial GlmU (Glucosamine 1-phosphate N-acetyltransferase/ N-acetylglucosamine-1-phosphate uridyltransferase) has been a target enzyme for drug discovery. Its C- and N- terminal domains… 
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