• Corpus ID: 1132442

Kinetic Modelling and Inference of Hyperpolarized 13C Molecules in Cancer Metabolism

  title={Kinetic Modelling and Inference of Hyperpolarized 13C Molecules in Cancer Metabolism},
  author={Junzhe Zhao},
  journal={arXiv: Biomolecules},
  • Junzhe Zhao
  • Published 20 December 2017
  • Biology, Computer Science
  • arXiv: Biomolecules
Hyperpolarized 13C-MRI allows real time observation of metabolism in vivo. Imaging sequences have been developed to follow the metabolism of [1-13C] pyruvate and extract reaction kinetics, which can show tumour treatment response. We applied the fitting model and algorithm for the imaging data of mice tumour models and determined error estimates for the parameters of interest. Data was least-squares fitted onto a two-site exchange model in MATLAB, followed by statistic computation to assess… 


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