Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection

@inproceedings{Leymarie2013KineticCO,
  title={Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection},
  author={Olivier Leymarie and Gr{\'e}gory Jouvion and Pierre-Louis Herv{\'e} and Christophe Chevalier and Val{\'e}rie Lorin and J{\'e}r{\^o}me Lecardonnel and Bruno Da Costa and Bernard Delmas and Nicolas Escriou and Ronan Le Goffic},
  booktitle={PloS one},
  year={2013}
}
The PB1-F2 protein encoded by influenza A viruses can contribute to virulence, a feature that is dependent of its sequence polymorphism. Whereas PB1-F2 from some H1N1 viruses were shown to exacerbate the inflammatory response within the airways, the contribution of PB1-F2 to highly pathogenic avian influenza virus (HPAIV) virulence in mammals remains poorly described. Using a H5N1 HPAIV strain isolated from duck and its PB1-F2 knocked-out mutant, we characterized the dynamics of PB1-F2… CONTINUE READING

Citations

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Evolution and Virulence of Influenza A Virus Protein PB1-F2

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