Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells

@article{Hirschberg1998KineticAO,
  title={Kinetic Analysis of Secretory Protein Traffic  and Characterization of Golgi to Plasma Membrane  Transport Intermediates in Living Cells },
  author={Koret Hirschberg and Chad M. Miller and Jan Ellenberg and John F. Presley and Eric D. Siggia and Robert D. Phair and Jennifer Lippincott-Schwartz},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={143},
  pages={1485 - 1503}
}
Quantitative time-lapse imaging data of single cells expressing the transmembrane protein, vesicular stomatitis virus ts045 G protein fused to green fluorescent protein (VSVG-GFP), were used for kinetic modeling of protein traffic through the various compartments of the secretory pathway. A series of first order rate laws was sufficient to accurately describe VSVG-GFP transport, and provided compartment residence times and rate constants for transport into and out of the Golgi complex and… CONTINUE READING
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