Kinetic, pharmacological and activity-dependent separation of two Ca2+ signalling pathways mediated by type 1 metabotropic glutamate receptors in rat Purkinje neurones.

Abstract

Type 1 metabotropic glutamate receptors (mGluR1) in Purkinje neurones (PNs) are important for motor learning and coordination. Here, two divergent mGluR1 Ca2+-signalling pathways and the associated membrane conductances were distinguished kinetically and pharmacologically after activation by 1-ms photorelease of L-glutamate or by bursts of parallel fibre… (More)

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@article{Canepari2006KineticPA, title={Kinetic, pharmacological and activity-dependent separation of two Ca2+ signalling pathways mediated by type 1 metabotropic glutamate receptors in rat Purkinje neurones.}, author={Marco Canepari and David A. Ogden}, journal={The Journal of physiology}, year={2006}, volume={573 Pt 1}, pages={65-82} }