Kinesin superfamily motor proteins and intracellular transport

@article{Hirokawa2009KinesinSM,
  title={Kinesin superfamily motor proteins and intracellular transport},
  author={Nobutaka Hirokawa and Yasuko Noda and Yosuke Tanaka and Shinsuke Niwa},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={682-696}
}
Intracellular transport is fundamental for cellular function, survival and morphogenesis. Kinesin superfamily proteins (also known as KIFs) are important molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs. The mechanisms by which different kinesins recognize and bind to specific cargos, as well as how kinesins unload cargo and determine the direction of transport, have now been identified. Furthermore, recent molecular… Expand
Kinesin Superfamily Proteins (KIFs) as a Fundamental Component of Life: Intracellular Transport and Beyond
TLDR
The history of and recent progress in KIF research in multiple disciplines, including molecular and cellular biology, molecular genetics, and structural biology, toward unraveling the roles and mechanisms of kinesin function are summarized. Expand
Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases.
TLDR
This review will summarize recent approaches to the regulation of the transport destinations and to the physiological relevance of the role of these proteins in neuroscience, ciliary functions, and metabolic diseases. Expand
Kinesin Superfamily Proteins
TLDR
The molecular mechanisms by which different kinesin superfamily proteins recognize and bind to specific cargoes, and how their binding is regulated, have been identified for some KIFs. Expand
Kinesin Superfamily Proteins
TLDR
The molecular mechanisms by which different kinesin superfamily proteins recognize and bind to specific cargoes, and how their binding is regulated, have been identified for some KIFs. Expand
The developmental biology of kinesins.
TLDR
This review highlights the specific developmental roles of kinesins, link these to cellular roles reported in vitro, and highlights remaining gaps in understanding of how this large and important family of proteins contributes to the development and morphogenesis of animals. Expand
Kinesin assembly and movement in cells.
TLDR
Recent studies on the three major families involved in intracellular transport (kinesin-1, kines in-2, and kinesIn-3) that have begun to bridge the gap in knowledge between the in vitro and in vivo behaviors of kinesin motors are discussed. Expand
The novel functions of kinesin motor proteins in plants
TLDR
A novel function of kinesins with transcription activation activity in regulating gibberellin biosynthesis and cell growth is reviewed, which will open exciting new areas ofkinesin research. Expand
Integrated regulation of motor-driven organelle transport by scaffolding proteins.
TLDR
This work has shown that organelle-associated scaffolding proteins, including Milton/TRAKs (trafficking kinesin-binding protein), JIP1, JIP3 (JNK-interacting proteins), huntingtin, and Hook1, interact with molecular motors to coordinate activity and sustain unidirectional transport. Expand
Traffic control: regulation of kinesin motors
TLDR
This work has revealed molecular mechanisms that control kinesin autoinhibition and subsequent activation, binding to cargos and microtubule tracks, and localization at specific sites of action. Expand
Kinesin Assembly and Movement in Cells
Long-distance transport in eukaryotic cells is driven by molecular motors that move along microtubule tracks. Molecular motors of the kinesin superfamily contain a kinesin motor domain attached toExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 179 REFERENCES
Kinesin and dynein superfamily proteins and the mechanism of organelle transport.
TLDR
This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins. Expand
Molecular motors and mechanisms of directional transport in neurons
TLDR
The molecular mechanisms of directional axonal and dendritic transport are discussed with specific emphasis on the role of motor proteins and their mechanisms of cargo recognition. Expand
Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics.
TLDR
New techniques using molecular biophysics, cryoelectron microscopy, and X-ray crystallography have detected structural changes in motor proteins, synchronized with ATP hydrolysis cycles, leading to the development of independent models of monomer and dimer motors for processive movement along microtubules. Expand
Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein
TLDR
It is proposed that sunday driver (syd) mediates the axonal transport of at least one class of vesicles by interacting directly with kinesin light chain (KLC) with K(d) congruent with 200 nM. Expand
Oligomeric Tubulin in Large Transporting Complex Is Transported via Kinesin in Squid Giant Axons
TLDR
It is shown that the directional movement of fluorescent profile was dependent on kinesin motor function, which revealed that tubulin molecule was transported in a unique form of large transporting complex distinct from those of stable polymers or other cytosolic protein. Expand
The Molecular Motor Toolbox for Intracellular Transport
TLDR
Remarkably, fungi, parasites, plants, and animals have distinct subsets of Toolbox motors in their genomes, suggesting an underlying diversity of strategies for intracellular transport. Expand
Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules
TLDR
Results demonstrate a direct interaction between conventional kinesin and a cargo, indicate that motor proteins are linked to their membranous cargo via scaffolding proteins, and support a role for motor proteins in spatial regulation of signal transduction pathways. Expand
The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.
TLDR
UNC-76 is an evolutionarily conserved cytosolic protein that binds to the tail domain of KHC in two-hybrid and copurification assays, indicating that kinesin and UNC-76 form a stable complex in vivo, and it is proposed that it helps integrate kinesIn activity in response to transport requirements in axons. Expand
Control of a Kinesin-Cargo Linkage Mechanism by JNK Pathway Kinases
TLDR
Evidence is reported that a Drosophila ubiquitin-specific hydrolase and a JNK signaling pathway that it modulates can regulate a JIP1-kinesin linkage and suggest a control mechanism in which an activated JNK pathway influences axonal transport by functioning as a kinesin-cargo dissociation factor. Expand
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head
TLDR
Findings revealed unique features of the microtubule cytoskeletons in the initial segment of axons, and suggested that they provide directional information for polarized axonal transport. Expand
...
1
2
3
4
5
...