Kinesin superfamily motor proteins and intracellular transport

@article{Hirokawa2009KinesinSM,
  title={Kinesin superfamily motor proteins and intracellular transport},
  author={Nobutaka Hirokawa and Yasuko Noda and Yosuke Tanaka and Shinsuke Niwa},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={682-696}
}
Intracellular transport is fundamental for cellular function, survival and morphogenesis. Kinesin superfamily proteins (also known as KIFs) are important molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs. The mechanisms by which different kinesins recognize and bind to specific cargos, as well as how kinesins unload cargo and determine the direction of transport, have now been identified. Furthermore, recent molecular… 

Kinesin assembly and movement in cells.

TLDR
Recent studies on the three major families involved in intracellular transport (kinesin-1, kines in-2, and kinesIn-3) that have begun to bridge the gap in knowledge between the in vitro and in vivo behaviors of kinesin motors are discussed.

Traffic control: regulation of kinesin motors

TLDR
This work has revealed molecular mechanisms that control kinesin autoinhibition and subsequent activation, binding to cargos and microtubule tracks, and localization at specific sites of action.

Kinesin Assembly and Movement in Cells

TLDR
Recent studies have increased the understanding of how kinesin subunits assemble to produce a functional motor, how kinein motors are affected by biochemical cues and obstacles present on cellular microtubules, and how multiple motors on a cargo surface can work collectively for increased force production and travel distance.

Linking molecular motors to membrane cargo.

Mechanisms for regulation of plant kinesins.

Kinesin superfamily proteins and the regulation of microtubule dynamics in morphogenesis

TLDR
The functions of these atypical KIFs that regulate microtubule dynamics are discussed and some interesting unanswered questions and hypothetical answers to them are discussed.
...

References

SHOWING 1-10 OF 167 REFERENCES

Kinesin and dynein superfamily proteins and the mechanism of organelle transport.

TLDR
This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.

Molecular motors and mechanisms of directional transport in neurons

TLDR
The molecular mechanisms of directional axonal and dendritic transport are discussed with specific emphasis on the role of motor proteins and their mechanisms of cargo recognition.

Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics.

TLDR
New techniques using molecular biophysics, cryoelectron microscopy, and X-ray crystallography have detected structural changes in motor proteins, synchronized with ATP hydrolysis cycles, leading to the development of independent models of monomer and dimer motors for processive movement along microtubules.

The Molecular Motor Toolbox for Intracellular Transport

Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein

Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules

TLDR
Results demonstrate a direct interaction between conventional kinesin and a cargo, indicate that motor proteins are linked to their membranous cargo via scaffolding proteins, and support a role for motor proteins in spatial regulation of signal transduction pathways.

The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.

TLDR
UNC-76 is an evolutionarily conserved cytosolic protein that binds to the tail domain of KHC in two-hybrid and copurification assays, indicating that kinesin and UNC-76 form a stable complex in vivo, and it is proposed that it helps integrate kinesIn activity in response to transport requirements in axons.

Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head

TLDR
Findings revealed unique features of the microtubule cytoskeletons in the initial segment of axons, and suggested that they provide directional information for polarized axonal transport.
...