Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.

@article{Hall1991KinesinrelatedGU,
  title={Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.},
  author={David H. Hall and Edward M. Hedgecock},
  journal={Cell},
  year={1991},
  volume={65 5},
  pages={837-47}
}
unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor in the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of… CONTINUE READING
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