Kinesin-related KIP3 of Saccharomyces cerevisiae Is Required for a Distinct Step in Nuclear Migration

@article{DeZwaan1997KinesinrelatedKO,
  title={Kinesin-related KIP3 of Saccharomyces cerevisiae Is Required for a Distinct Step in Nuclear Migration },
  author={Todd M. DeZwaan and Eric Ellingson and David S Pellman and David M. Roof},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={138},
  pages={1023 - 1040}
}
Spindle orientation and nuclear migration are crucial events in cell growth and differentiation of many eukaryotes. Here we show that KIP3, the sixth and final kinesin-related gene in Saccharomyces cerevisiae, is required for migration of the nucleus to the bud site in preparation for mitosis. The position of the nucleus in the cell and the orientation of the mitotic spindle was examined by microscopy of fixed cells and by time-lapse microscopy of individual live cells. Mutations in KIP3 and in… CONTINUE READING
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