Kinesin Superfamily Protein 2A (KIF2A) Functions in Suppression of Collateral Branch Extension

  title={Kinesin Superfamily Protein 2A (KIF2A) Functions in Suppression of Collateral Branch Extension},
  author={Noriko Homma and Yosuke Takei and Yosuke Tanaka and Takao Nakata and Sumio Terada and Masahide Kikkawa and Yasuko Noda and Nobutaka Hirokawa},
Through interactions with microtubules, the kinesin superfamily of proteins (KIFs) could have multiple roles in neuronal function and development. During neuronal development, postmitotic neurons develop primary axons extending toward targets, while other collateral branches remain short. Although the process of collateral branching is important for correct wiring of the brain, the mechanisms involved are not well understood. In this study, we analyzed kif2a(-/-) mice, whose brains showed… CONTINUE READING

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