Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array

@article{Myers2007Kinesin5RT,
  title={Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array},
  author={Kenneth A Myers and Peter W. Baas},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={1081 - 1091}
}
Kinesin-5 is a homotetrameric motor protein that interacts with adjacent microtubules in the mitotic spindle. Kinesin-5 is also highly expressed in developing postmitotic neurons. Axons of cultured neurons experimentally depleted of kinesin-5 grow up to five times longer than controls and display more branches. The faster growth rates are accompanied by a doubling of the frequency of transport of short microtubules, suggesting a major role for kinesin-5 in the balance of motor-driven forces on… CONTINUE READING

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Expression of the mitotic kinesin Kif 15 in postmitotic neurons : implications for neuronal migration and development

  • M. C. Alonso
  • J . Neurocytol .
  • 2004

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