Kinesin-5 Is Essential for Growth-Cone Turning

@article{Nadar2008Kinesin5IE,
  title={Kinesin-5 Is Essential for Growth-Cone Turning},
  author={Vidya C. Nadar and Andrea R Ketschek and Kenneth A Myers and Gianluca Gallo and Peter W. Baas},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={1972-1977}
}
Inhibition of kinesin-5, a mitotic motor protein also expressed in neurons, causes axons to grow faster as a result of alterations in the forces on microtubules (MTs) in the axonal shaft. Here, we investigate whether kinesin-5 plays a role in growth-cone guidance. Growth-cone turning requires that MTs in the central (C-) domain enter the peripheral (P-) domain in the direction of the turn. We found that inhibition of kinesin-5 in cultured neurons prevents MTs from polarizing within growth cones… CONTINUE READING
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