Kinesin-4 KIF21B is a potent microtubule pausing factor

  title={Kinesin-4 KIF21B is a potent microtubule pausing factor},
  author={Wilhelmina E. van Riel and Ankit Rai and Sarah Bianchi and Eugene A. Katrukha and Qingyang Liu and Albert J. R. Heck and Casper C Hoogenraad and Michel O. Steinmetz and Lukas C Kapitein and Anna Akhmanova},
Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus ends and induce pausing. A few KIF21B molecules are sufficient to induce strong growth inhibition of a microtubule plus end in vitro. This property depends on non-motor microtubule-binding domains located in the stalk region and the C-terminal WD40… CONTINUE READING
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Publications referenced by this paper.
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Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations

S Bianchi, WE van Riel, +11 authors RA. Kammerer
Scientific Reports 6:30668. doi: 10.1038/srep30668, • 2016
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EA Katrukha, B Cloin, J Teeuw, LC. Kapitein
463a32f541ebd76d910c1c4e593c189c382b3fb9. • 2016
View 3 Excerpts
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EA Katrukha, B Cloin, J Teeuw, LC Kapitein
View 2 Excerpts
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Microtubule-depolymerizing kinesins.

Annual review of cell and developmental biology • 2013
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Move in for the kill: motile microtubule regulators.

Trends in cell biology • 2012
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