Kinesin-4 KIF21B is a potent microtubule pausing factor

@inproceedings{Riel2017Kinesin4KI,
  title={Kinesin-4 KIF21B is a potent microtubule pausing factor},
  author={Wilhelmina E. van Riel and Ankit Rai and Sarah Bianchi and Eugene A. Katrukha and Qingyang Liu and Albert J. R. Heck and Casper C Hoogenraad and Michel O. Steinmetz and Lukas C Kapitein and Anna Akhmanova},
  booktitle={eLife},
  year={2017}
}
Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus ends and induce pausing. A few KIF21B molecules are sufficient to induce strong growth inhibition of a microtubule plus end in vitro. This property depends on non-motor microtubule-binding domains located in the stalk region and the C-terminal WD40… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 69 references

Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations

S Bianchi, WE van Riel, +11 authors RA. Kammerer
Scientific Reports 6:30668. doi: 10.1038/srep30668, • 2016
View 5 Excerpts
Highly Influenced

Detection of Molecules plugin for ImageJ

EA Katrukha, B Cloin, J Teeuw, LC. Kapitein
463a32f541ebd76d910c1c4e593c189c382b3fb9. https://github.com/ekatrukha/DoM_Utrecht • 2016
View 3 Excerpts
Highly Influenced

ImageJ plugin detecting and colocalizing particles of given size . 3 e 0 dfda 90354 f 968 fd 9 ba 2 bf 25928186993 c 1 ea 2

EA Katrukha, B Cloin, J Teeuw, LC Kapitein
2016
View 2 Excerpts
Highly Influenced

Microtubule-depolymerizing kinesins.

Annual review of cell and developmental biology • 2013
View 3 Excerpts
Highly Influenced

Move in for the kill: motile microtubule regulators.

Trends in cell biology • 2012
View 5 Excerpts
Highly Influenced

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