Kinesin-12 Kif15 Targets Kinetochore Fibers through an Intrinsic Two-Step Mechanism

@article{Sturgill2014Kinesin12KT,
  title={Kinesin-12 Kif15 Targets Kinetochore Fibers through an Intrinsic Two-Step Mechanism},
  author={Emma G. Sturgill and Dibyendu Kumar Das and Yoshimasa Takizawa and Yongdae Shin and Scott E. Collier and Melanie D. Ohi and Wonmuk Hwang and Matthew J. Lang and Ryoma Ohi},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={2307-2313}
}
Proteins that recognize and act on specific subsets of microtubules (MTs) enable the varied functions of the MT cytoskeleton. We recently discovered that Kif15 localizes exclusively to kinetochore fibers (K-fibers) or bundles of kinetochore-MTs within the mitotic spindle. It is currently speculated that the MT-associated protein TPX2 loads Kif15 onto spindle MTs, but this model has not been rigorously tested. Here, we show that Kif15 accumulates on MT bundles as a consequence of two inherent… CONTINUE READING

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