Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming.

@article{Moua2011Kinesin1TA,
  title={Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming.},
  author={Pangkong Moua and Donna M Fullerton and Laura R. Serbus and Rahul Warrior and William M. Saxton},
  journal={Development},
  year={2011},
  volume={138 6},
  pages={1087-92}
}
The N-terminal head domain of kinesin heavy chain (Khc) is well known for generating force for transport along microtubules in cytoplasmic organization processes during metazoan development, but the functions of the C-terminal tail are not clear. To address this, we studied the effects of tail mutations on mitochondria transport, determinant mRNA localization and cytoplasmic streaming in Drosophila. Our results show that two biochemically defined elements of the tail - the ATP-independent… CONTINUE READING

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