Kinesin, 30 years later: Recent insights from structural studies

  title={Kinesin, 30 years later: Recent insights from structural studies},
  author={W. Wang and Luyan Cao and Chunguang Wang and B. Gigant and Marcel Knossow},
  journal={Protein Science},
  • W. Wang, Luyan Cao, +2 authors Marcel Knossow
  • Published 2015
  • Biology, Medicine
  • Protein Science
  • Motile kinesins are motor proteins that move unidirectionally along microtubules as they hydrolyze ATP. They share a conserved motor domain (head) which harbors both the ATP‐ and microtubule‐binding activities. The kinesin that has been studied most moves toward the microtubule (+)‐end by alternately advancing its two heads along a single protofilament. This kinesin is the subject of this review. Its movement is associated to alternate conformations of a peptide, the neck linker, at the C… CONTINUE READING
    27 Citations
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