Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats.

@article{Lscher1991KindlingAA,
  title={Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats.},
  author={Wolfgang L{\"o}scher and Chris Rundfeldt},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={258 2},
  pages={483-9}
}
Complex partial seizures comprise the major uncontrolled seizure type in adult patients with epilepsy. Any improvement of our understanding of the mechanisms through which these seizures are often refractory to antiepileptic drugs is therefore of considerable importance. By examining the effects of the anti-epileptic drug phenytoin in a large group of kindled rats, a widely used model of complex partial seizures, animals with different sensitivity to this drug were selected. Using determination… CONTINUE READING