Kindling as a model for alcohol withdrawal syndromes.

@article{Ballenger1978KindlingAA,
  title={Kindling as a model for alcohol withdrawal syndromes.},
  author={JamesC. Ballenger and Robert M Post},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1978},
  volume={133},
  pages={
          1-14
        }
}
Periodic brain stimulation, particularly in the limbic system, at stimulus intensities initially too low to produce any behavioural or EEG effects, progressively produces EEG changes, motor automatisms, and eventually convulsions, an effect called kindling. Data are presented and reviewed that suggest that the severity of alcohol withdrawal symptoms progressively increases over years of alcohol abuse in a stepwise fashion similar to the kindling process. The model is presented that the limbic… CONTINUE READING

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