Kindlin1 regulates microtubule function to ensure normal mitosis

  title={Kindlin1 regulates microtubule function to ensure normal mitosis},
  author={Hitesh Patel and Ifigeneia Stavrou and Roshan L Shrestha and Viji M Draviam and Margaret C Frame and Valerie G Brunton},
  booktitle={Journal of molecular cell biology},
Loss of Kindlin 1 (Kin1) results in the skin blistering disorder Kindler Syndrome (KS), whose symptoms also include skin atrophy and reduced keratinocyte proliferation. Kin1 binds to integrins to modulate their activation and more recently it has been shown to regulate mitotic spindles and cell survival in a Plk1-dependent manner. Here we report that short-term Kin1 deletion in mouse skin results in impaired mitosis, which is associated with reduced acetylated tubulin (ac-tub) levels and cell… CONTINUE READING
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