Corpus ID: 52197223

Kindlin-2-mediated upregulation of ZEB2 facilitates migration and invasion of oral squamous cell carcinoma in a miR-200b-dependent manner.

  title={Kindlin-2-mediated upregulation of ZEB2 facilitates migration and invasion of oral squamous cell carcinoma in a miR-200b-dependent manner.},
  author={W. Ren and L. Gao and Cui Qiang and Shaoming Li and Jingjing Zheng and Qibo Wang and Yuan Zhi and G. Cai and Xinjuan Kong and Minzhan Zhou and Zhigang Qu and K. Zhi},
  journal={American journal of translational research},
  volume={10 8},
  • W. Ren, L. Gao, +9 authors K. Zhi
  • Published 2018
  • Biology, Medicine
  • American journal of translational research
  • The miR-200 family suppresses epithelial-mesenchymal transition by inhibiting ZEB1 and ZEB2 mRNA translation in several types of cancers. Kindlin-2 is a target gene of miR-200b and its expression level correlates positively to ZEB2 in oral squamous cell carcinoma (OSCC). Whether Kindlin-2 and ZEB2 share a competitive endogenous RNAs regulatory network in OSCC remains unclear. Here, we studied the expression levels of miR-200b, Kindlin-2, and ZEB2 and found direct interaction between miR-200b… CONTINUE READING
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