Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes.

@article{Herz2006Kindlin1IA,
  title={Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes.},
  author={Corinna Herz and Monique Aumailley and Carsten Schulte and Ursula M. Schl{\"o}tzer-Schrehardt and Leena Bruckner-Tuderman and Cristina Has},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 47},
  pages={36082-90}
}
A novel family of focal adhesion proteins, the kindlins, is involved in attachment of the actin cytoskeleton to the plasma membrane and in integrin-mediated cellular processes. Deficiency of kindlin-1, as a result of loss-of-function mutations in the KIND1 gene, causes Kindler syndrome, an autosomal recessive genodermatosis characterized by skin blistering, progressive skin atrophy, photosensitivity and, occasionally, carcinogenesis. Here we characterized authentic and recombinantly expressed… CONTINUE READING
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