Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors.

Protein kinases continue to hold tremendous promise for therapeutic intervention, and the search for novel, safe and efficacious kinase inhibitors has intensified over the past decade. Given that most kinases are readily inhibited by organic small molecules and that a wealth of structural data exists on kinase-inhibitor complexes, there has been almost… CONTINUE READING
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