Kinase-targeted cancer therapies: progress, challenges and future directions

@inproceedings{Bhullar2018KinasetargetedCT,
  title={Kinase-targeted cancer therapies: progress, challenges and future directions},
  author={Khushwant Singh Bhullar and Naiara Orrego Lagar{\'o}n and Eileen M McGowan and Indu Parmar and Amitabh Jha and Basil P. Hubbard and H. P. Vasantha Rupasinghe},
  booktitle={Molecular Cancer},
  year={2018}
}
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with human cancer initiation and progression. The recent development of small-molecule kinase inhibitors for the treatment of diverse types of cancer has proven successful in clinical therapy. Significantly, protein kinases are the second most targeted group of drug targets, after the G-protein-coupled receptors. Since the… CONTINUE READING
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