Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli.

@article{Shcherbakova2010KinaserelatedPI,
  title={Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli.},
  author={Olga V Shcherbakova and Daria V Serebryanaya and Alexander B Postnikov and Mechthild M. Schroeter and Stefan Zittrich and Angelika A. Noegel and Vladimir P Shirinsky and Alexander V Vorotnikov and Gabriele Pfitzer},
  journal={The Biochemical journal},
  year={2010},
  volume={429 2},
  pages={291-302}
}
KRP (kinase-related protein), also known as telokin, has been proposed to inhibit smooth muscle contractility by inhibiting the phosphorylation of the rMLC (regulatory myosin light chain) by the Ca2+-activated MLCK (myosin light chain kinase). Using the phosphatase inhibitor microcystin, we show in the present study that KRP also inhibits Ca2+-independent rMLC phosphorylation and smooth muscle contraction mediated by novel Ca2+-independent rMLC kinases. Incubating KRP-depleted Triton-skinned… CONTINUE READING
4 Citations
49 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 49 references

291–302 (Printed in Great Britain) doi:10.1042/BJ20090819 SUPPLEMENTARY ONLINE DATA Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli

  • J. Biochem
  • Olga V. SHCHERBAKOVA*1,
  • 2010

Similar Papers

Loading similar papers…