Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation.

@article{Thomas2014KinasemediatedCI,
  title={Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation.},
  author={Colin J Thomas and Elena Y Kotova and Mark D Andrake and Jared Adolf-Bryfogle and Robert L. Glaser and Catherine Regnard and Alexei V. Tulin},
  journal={Molecular cell},
  year={2014},
  volume={53 5},
  pages={831-42}
}
Dynamically controlled posttranslational modifications of nucleosomal histones alter chromatin condensation to regulate transcriptional activation. We report that a nuclear tandem kinase, JIL-1, controls gene expression by activating poly(ADP-ribose) polymerase-1 (PARP-1). JIL-1 phosphorylates the C terminus of the H2Av histone variant, which stimulates PARP-1 enzymatic activity in the surrounding chromatin, leading to further modification of histones and chromatin loosening. The H2Av… CONTINUE READING
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