Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism.


Macromolecular function is rooted in energy landscapes, where sequence determines not a single structure but an ensemble of conformations. Hence, evolution modifies a protein's function by altering its energy landscape. Here, we recreate the evolutionary pathway between two modern human oncogenes, Src and Abl, by reconstructing their common ancestors. Our… (More)
DOI: 10.1126/science.aaa1823


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