Kinase-activity-independent functions of atypical protein kinase C in Drosophila.

  title={Kinase-activity-independent functions of atypical protein kinase C in Drosophila.},
  author={Soya Kim and Ieva Gailite and Bernard Moussian and Stefan Luschnig and Maik Goette and Karen Fricke and Mona Honemann-Capito and Helmut Grubm{\"u}ller and Andreas Wodarz},
  journal={Journal of cell science},
  volume={122 Pt 20},
Polarity of many cell types is controlled by a protein complex consisting of Bazooka/PAR-3 (Baz), PAR-6 and atypical protein kinase C (aPKC). In Drosophila, the Baz-PAR-6-aPKC complex is required for the control of cell polarity in the follicular epithelium, in ectodermal epithelia and neuroblasts. aPKC is the main signaling component of this complex that functions by phosphorylating downstream targets, while the PDZ domain proteins Baz and PAR-6 control the subcellular localization and kinase… CONTINUE READING


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