Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

  title={Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase},
  author={Yuhua Zhang and Bei Yao and Sylvie Delikat and Shariff S Bayoumy and Xin-hua Lin and Subham Basu and Michael J. McGinley and Po-Ying Chan-Hui and Henri Lichenstein and Richard N. Kolesnick},
A proline-directed serine/threonine ceramide-activated protein (CAP) kinase mediates transmembrane signaling through the sphingomyelin pathway. CAP kinase reportedly initiates proinflammatory TNF alpha action by phosphorylating and activating Raf-1. The present studies delineate kinase suppressor of Ras (KSR), identified genetically in Caenorhabditis elegans and Drosophila, as CAP kinase. Mouse KSR, like CAP kinase, renatures and autophosphorylates as a 100-kDa membrane-bound polypeptide. KSR… CONTINUE READING
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