Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

@article{Zhang1997KinaseSO,
  title={Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase},
  author={Yuhua Zhang and Bei Yao and Sylvie Delikat and Shariff S Bayoumy and Xin-hua Lin and Subham Basu and Michael J. McGinley and Po-Ying Chan-Hui and Henri Lichenstein and Richard N. Kolesnick},
  journal={Cell},
  year={1997},
  volume={89},
  pages={63-72}
}
A proline-directed serine/threonine ceramide-activated protein (CAP) kinase mediates transmembrane signaling through the sphingomyelin pathway. CAP kinase reportedly initiates proinflammatory TNF alpha action by phosphorylating and activating Raf-1. The present studies delineate kinase suppressor of Ras (KSR), identified genetically in Caenorhabditis elegans and Drosophila, as CAP kinase. Mouse KSR, like CAP kinase, renatures and autophosphorylates as a 100-kDa membrane-bound polypeptide. KSR… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.
131 Citations
26 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 131 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

KSR , a novel protein kinase requiredcytosolic protein phosphatase

  • M. Therrien, H. C. Chang, +5 authors G. M. Rubin
  • J . Biol . Chem .
  • 1995
Highly Influential
7 Excerpts

, receptor initiates the neutral sphingomyelinase pathway

  • G. Sithanandam, T. D. Copeland, D. R. Kaplan
  • J . Biol .
  • 1996

Signal transduc - the p 55 TNF - receptor to neutral sphingomyelinase

  • D. Adam, K. Wiegmann, S. Adam-Klages, A. Ruff, M. Kronke
  • Cell
  • 1996
1 Excerpt

Compartmentalized produc - VRKRTLRRL ( PKC ) . The Raf - 1 peptides and the substrate peptides tion of ceramide at the cell surface

  • J. Lozano, E. Berra, M. M. Municio, L. Sanz, J. Moscat
  • J . Biol . Chem .
  • 1995

Similar Papers

Loading similar papers…