Kinase Is Required for Efficient Transcription Elongation by RNA Polymerase II

@inproceedings{Keogh2003KinaseIR,
  title={Kinase Is Required for Efficient Transcription Elongation by RNA Polymerase II},
  author={M C Keogh and Vladimir Podolny and Stephen Buratowski},
  year={2003}
}
The Saccharomyces cerevisiae cyclin-dependent kinase (CDK) Bur1 (Sgv1) may be homologous to mammalian Cdk9, which functions in transcriptional elongation. Although Bur1 can phosphorylate the Rpb1 carboxyterminal domain (CTD) kinase in vitro, it has no strong specificity within the consensus heptapeptide YSPTSPS for Ser2 or Ser5. BUR1 mutants are sensitive to the drugs 6-azauracil and mycophenolic acid and interact genetically with the elongation factors Ctk1 and Spt5. Chromatin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Similar Papers

Loading similar papers…