Kinase (RON), a c-MET Family Member to the Macrophage-Stimulating Protein Receptor Tyrosine Therapeutic Implications of a Human Neutralizing Antibody


RON is a member of the c-MET receptor tyrosine kinase family. Like c-MET, RON is expressed by a variety of epithelial-derived tumors and cancer cell lines and it is thought to play a functional role in tumorigenesis. To date, antagonists of RON activity have not been tested in vivo to validate RON as a potential cancer target. In this report, we used an… (More)


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