Kin I Kinesins Are Microtubule-Destabilizing Enzymes

@article{Desai1999KinIK,
  title={Kin I Kinesins Are Microtubule-Destabilizing Enzymes},
  author={Arshad Desai and Suzie Verma and Timothy J Mitchison and Claire E Walczak},
  journal={Cell},
  year={1999},
  volume={96},
  pages={69-78}
}
Using in vitro assays with purified proteins, we show that XKCM1 and XKIF2, two distinct members of the internal catalytic domain (Kin I) kinesin subfamily, catalytically destabilize microtubules using a novel mechanism. Both XKCM1 and XKIF2 influence microtubule stability by targeting directly to microtubule ends where they induce a destabilizing… CONTINUE READING